Endotype of Allergic Asthma with Airway Obstruction in Urban Children

In the first decade of life, high-asthma risk urban children develop stable phenotypes of respiratory health versus disease that link early life environmental exposures to childhood allergic sensitization and asthma. Moreover, unique patterns of nasal gene expression demonstrate how specific molecular pathways underlie distinct respiratory phenotypes, including allergic and non-allergic asthma. URECA is a high risk asthma birth cohort study. These samples are nasal brush samples taken at age 11. They were used to identify airway gene expression patterns that associate with clinical phenotypes over time.