Pharmacological Evaluation of Local Malaysian Fruits and their Phytochemicals for Epileptic Seizure-like Activity in Zebrafish Larvae Model

Despite having multiple generations of anti-seizure medication, about a third of people with epilepsy (PWE) are drug-resistant and suffer from recurrent seizures. Hence, there is a need to find alternative methods to achieve seizure control and improve quality of life. Fruits are a promising alternative that are rich in vitamins, minerals, and bioactive compounds. This study evaluates three commonly consumed tropical fruits in Southeast Asia, including Malaysia, durian, mangosteen, and rambutan, for pro- and anti-seizure activity using zebrafish larvae seizure model. This study aims to evaluate fruits that can work against or synergistically with the currently available treatments for epilepsy.