Differentially regulated proteins after 2.0 Gy irradiation using ICPL approach.

Mitochondrial proteins from 2 Gy-irradiated and sham-irradiated hearts were labeled with the heavy and light isotopes, respectively. The proteins demonstrated in the table were identified by two or more unique peptides. Theoretical isoelectric points (pI) and molecular weights (Mw) are derived from the amino acid sequences in Swiss-Prot. All proteins showing significant (p <0.05; Perseus Statistics program) upregulation (>1.3-fold) or downregulation (<0.770-fold) were considered as deregulated. Replicate protein ratios were averaged to take account for biological variability. Spread of the ratios for one protein over biological replicates is given as %CV (Fold change Variability).