Potent Beta-Secretase 1 hydroxyethylene Inhibitor

Potent Beta-Secretase 1 hydroxyethylene Inhibitor Descriptor: Beta-secretase 1, N-[(2S,3S,5R)-1-(3,5-difluorophenoxy)-3-hydroxy-5-(2-methoxyethoxy)-6-[[(2S)-3-methyl-1-oxo-1-(phenylmethylamino)butan-2-yl]amino]-6-oxo-hexan-2-yl]-5-(methyl-methylsulfonyl-amino)-N'-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide Authors: Lindberg, J.D, Borkakoti, N, Nystrom, S. Deposit date: 2009-06-29 Release date: 2010-06-02 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Discovery of potent BACE-1 inhibitors containing a new hydroxyethylene (HE) scaffold: exploration of P1' alkoxy residues and an aminoethylene (AE) central core Bioorg.Med.Chem., 18, 2010