FIRRM binds PLK1
收藏reactome.org2025-01-16 收录
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资源简介:
FIRRM (also known as Apolo1, FINGL1-interacting regulator of recombination and mitosis, FLIP or C1orf112) colocalizes with PLK1 to kinetochores during prometaphase. The N-terminus of FIRRM (amino acids 1-176) binds to the C-terminal polo-box domain (PBD) of PLK1 (Xu et al. 2021).
FIRRM(亦称Apolo1、FINGL1互作重组和有丝分裂调节因子、FLIP或C1orf112)在前期与PLK1共定位至着丝粒。FIRRM的N端(氨基酸1-176)与PLK1的C端 polo-box 结构域(PBD)结合(Xu等,2021年)。
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