Effect of the iHsp90 CCT018159 on the melanoma antigen gp100 in the mouse B-16 cell line.

aCells were untreated (control) or treated with the Hsp90 inhibitor CCT018159 as indicated for 3 days.bDose indicated is optimal dose for antigen increasecNumber represents geometric mean of intracellular staining with an antibody to gp100 of live gated cells. Number in parenthesis is fold increase relative to untreated control.dNumber represents the fold increase relative to untreated control. Fold difference is calculated as 2-ΔΔCt (Materials and Methods).p value from Student t test comparing iHsp90-treated cells to control. Data are highly significant with respect to control values for each of the comparisons shown.Effect of the iHsp90 CCT018159 on the melanoma antigen gp100 in the mouse B-16 cell line.