Additional file 1 of Genetically predicted plasma levels of amino acids and metabolic dysfunction-associated fatty liver disease risk: a Mendelian randomization study

Additional file 1: Table S1. Proxy SNPs of genetic instruments identified in the MAFLD summary data. Table S2. Characteristics of SNPs instrumenting for amino acids in the MR analysis. Table S3. Genetic associations between genetic instrumental variables and MAFLD in two GWAS data used for discovery and replication analysis. Table S4. Proportion of variation in amino acids explained by genetic instruments. Table S5. Heterogeneity tested between SNP-specific causal estimates in the discovery MR analysis. Table S6. MR sensitivity analysis results using weighted median and MR-Egger regression methods. Table S7. Genetic variants associated with BMI, waist-to-hip ratio and whole body fat mass by searching the PhenoScanner database. Table S8. MR analysis results for each individual cohort and Cochrane’s Q statistic.