Allelic association in bipolar 1 patients with cognitive manic symptoms (CMS) patients compared to non-CMS and to ABD controls in the DAOA and COMT genes.

aSNP (minor allele(a)/major allele(b)).bgender and rs1718119 as covariate.cpoint-wise p-value from 10,000 pemutations with no covarite (EMP1).dcorrected empirical p-value by max (T) permutation.eodds ratio (OR), the proportion of minor versus major allele affected (cognitive manic symptoms factor)/proportion of minor versus major allele unaffected (non-cognitive manic symptoms factor or ABD controls).*significant after correction for multiple testing by max (T) permutation.