Serum proteomic analysis of the great obstetrical syndromes

The great obstetrical syndromes (GOS) encompass a spectrum of pregnancy-related complications associated with defective deep placentation, including hypertensive pregnancies, preterm birth, and fetal growth restriction. We performed pre-symptomatic phase proteomic profiling of serum samples from 384 nulliparas and 65 multiparas to characterize the molecular changes prior to the onset of different GOS conditions.