A giant virus genome is densely packaged by stable nucleosomes within virions. The two doublet histones of Marseillevirus are distantly related to the four eukaryotic core histones and wrap 121 basepa
Histone H4 can be acetylated at N-terminal lysines K5, K8, K12, and K16, but newly synthesized H4 is diacetylated at K5/K12 in diverse organisms. This pattern is widely thought to be important for his