Synthetic reproducibility simulator and generated dataset inspired by "Towards optimally replacing the current version of MELD"

This repository contains a synthetic simulator, source code, generated synthetic data, and documentation inspired by the Letter to the Editor, “Towards optimally replacing the current version of MELD” (Journal of Hepatology, 2023). The goal of this repository is to provide a computational companion that translates the published conceptual and methodological content into an executable form for exploration, reproducibility, and educational use.

The repository does not contain the original patient-level clinical data from the publication. Instead, it contains a synthetic simulation environment built from information described in the published letter and related cited sources, together with explicit assumptions where details were not fully specified in the article. The resulting outputs should therefore be interpreted as synthetic, research-oriented artifacts inspired by the publication rather than as a direct recovery of the original study dataset.

Included materials may contain:

source code for the simulator

synthetic datasets generated by the simulator

documentation describing assumptions, variables, parameters, scenarios, and outputs

figures and tables produced from the synthetic runs

The simulator is intended to help readers, researchers, educators, and developers examine how a published methodological idea can be operationalized into executable code and structured synthetic outputs. It may also serve as an example of how narrative scientific publications can be transformed into reusable computational companions.

This repository is best understood as a reproducibility-oriented and exploratory resource. It is not a clinical decision tool, not a validated medical product, and not a substitute for the original publication or its underlying data. Users should review the accompanying documentation for details on assumptions, limitations, and interpretation.