HVN Antidiabetic Metadata Record - The effect of antidiabetic drugs on the metabolism of peripheral blood immune cells

This metadata record and it's attached files make statements about the kinds of data collected as part of this research, and set out policies for governance of that data, now and in the future.Description: The objective of this study is to investigate whether or not antidiabetic drugs influence the cellular metabolism of peripheral blood immune cells. Blood samples of up to 100 participants with type 2 diabetes will be collected before and around 12 weeks after starting a new antidiabetic treatment. Blood samples will be analysed to determine if there is a correlation between successful anti-diabetic treatment, as assessed by decreased HbA1c and/or fasting plasma glucose, and any of the immunometabolic outcomes. Secondary analyses will explore whether the different anti-diabetic treatments influence cellular immunometabolism in different ways.

本元数据记录及其所附文件对作为本研究一部分所收集的数据类型做出陈述，并规定了该数据现在及未来治理的政策。研究目的在于探究抗糖尿病药物是否影响外周血免疫细胞的细胞代谢。将收集最多100名2型糖尿病患者的血液样本，分别在开始新的抗糖尿病治疗前后及治疗开始后约12周进行。通过对血液样本的分析，旨在确定成功抗糖尿病治疗（通过降低HbA1c和/或空腹血糖水平评估）与任何免疫代谢结果之间的相关性。次要分析将探究不同的抗糖尿病治疗是否以不同的方式影响细胞免疫代谢。