Formation of the 'destruction complex'

The 'destruction complex' is formed from the large scaffolding proteins Axin (AXN) and APC (APC/APC2). This enables regulating molecules such as the kinases, CKIalpha, DCO, and Shaggy (SGG) and the phosphatase, PP2A to be held together in close proximity where they can regulate the phosphorylation of the scaffolding molecules and cytoplasmic Armadillo (ARM). The protein serine/threonine phosphatase PP2A is made up of the regulatory subunit A, PP2A-29B; the regulatory subunit B, Twins (TWS); and the catalytic subunit C, Microtubule star (MTS).

‘破坏复合体’由大型支架蛋白Axin（AXN）和APC（APC/APC2）构成。此结构使得诸如激酶、CKIalpha、DCO和Shaggy（SGG）等调节分子以及磷酸酶PP2A得以在紧密的空间内聚合，从而实现对支架分子和细胞质中Armadillo（ARM）的磷酸化进行调控。蛋白质丝氨酸/苏氨酸磷酸酶PP2A由调节亚基A、PP2A-29B；调节亚基B、Twins（TWS）；以及催化亚基C、微管星（MTS）组成。