List of compounds used to validate the assay.
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Their host cell toxicity (TC50) and anti-T. cruzi (IC50 for the ‘Am/Cell’ and ‘%Infectivity’ assay outputs) mean values of three independent experiments plus their sd are shown (mean ± sd).
aIC50 values for the ‘Am/Cell’ output;
bIC50 values for the ‘%Infected’ output;
cratio between the mean TC50 values and their corresponding ‘Am/Cell’ IC50 measurement.
dliterature reference;
end, not determined;
#values obtained at the anti-Chagas HTS campaign recently performed at GSK (Peña et al., manuscript in preparation);
*not actually an IC50 value but the minimal compound dose to eradicate T. cruzi amastigotes in Vero cells [26].
List of compounds used to validate the assay.
创建时间：
2015-01-23
