Exploratory eight-gene hypoxia/proliferation-immune expression axis in lung adenocarcinoma: cross-cohort public-data transportability analysis

Derived source data, analysis outputs, figures, and scripts for an exploratory eight-gene lung adenocarcinoma (LUAD) expression-axis transportability analysis. The fixed axis is mean[z(CA9), z(MKI67), z(STAT1), z(HIF1A)] minus mean[z(CD4), z(CD8A), z(CD8B), z(TIGIT)], with equal weights and no survival-driven refitting. The primary external overall-survival analysis included GSE72094, GSE42127, GSE50081, and GSE19188; GSE41271 was reserved for date-derived overall-survival sensitivity analysis; GSE31210 was retained as a relapse-free-survival secondary reference; and GSE30219 was excluded from overall-survival pooling because its available endpoint was relapse-related. The package preserves proportional-hazards diagnostics, heterogeneity, prediction intervals, leave-one-cohort-out results, figure source data, and analysis scripts. It excludes raw CEL files, GEO Series Matrix files, platform annotation archives, restricted individual-level data, the manuscript, and cover letter. These files support exploratory reproducibility and transportability assessment; they do not establish a validated prognostic signature, clinical utility, treatment-prediction biomarker, causal mechanism, independent clinical validation, or prospective performance. Data and figures are intended for CC BY 4.0; code is intended for MIT licensing.