BackgroundNon-motor symptoms are common in Parkinson’s disease (PD) and can even be used as part of the supportive criteria for diagnosis. Chronic inflammation is involved in every stage of PD. Disord
3D viSNE representation of microglial modules: DAM (Red) and Homeostatic (Black) genes identified by single-cell RNAseq mapped to WGCNA modules. (HTML 3818 kb)
Sorted CD45⁺ meningeal immune cells from dorsal root ganglia (DRGs) were obtained and processed for droplet-based single-cell RNA sequencing using the 10x Genomics Chromium platform. Single-cell suspe
a- Significant difference from the control group P<0.0001 b- Significant difference from NSSL-50mg/kg group P<0.005 c- Significant difference from the control group P<0.05. Comparison of the therapeut
Myelination of axons enables efficient signal propagation in neurones. Myelin is a multi-layered membrane that wraps around neuronal axons forming extremely tight contacts that insulate the axon. Tigh
