Single-Cell Analyses Elucidate the Cellular and Molecular Landscape of Ulcerative Colitis

Inflammatory bowel disease (IBD) encompasses a spectrum of complex intestinal disorders characterized by dysregulated host innate and adaptive immune responses to gut microbiota in genetically susceptible hosts. We generated an integrated single-cell (scRNA-seq, scTCR-seq, and scBCR-seq) resource dataset that revealed key cellular components and cell states of the gastrointestinal mucosal and peripheral immune systems in health and ulcerative colitis (UC). Single-cell RNA-seq and BCR/TCR repertoire analyses of immune cell from 15 patients