Gene expression changes of 4,4'-thiobis(6-tert-butyl-m-cresol)-induced in renal cortex of rats. Rattus norvegicus

This study is to develop a short term and highly accurate prediction method of renal carcinogenicity based on gene expression profile of rats administrated by carcinogens. We conducted 28 days-repeated dose experiments in male SD rats with 4,4'-thiobis(6-tert-butyl-m-cresol), and the gene expression profiles of renal cortex were analyzed using custom microarrays. Overall design: Experimental design is the two group (control group vs. 4,4'-thiobis(6-tert-butyl-m-cresol) treated group). Three biological replicates were performed for each group.