Performance of Risk Models for Antimicrobial Resistance in Adult Patients with Sepsis

This was a retrospective cohort study (N = 39,893) conducted from January 2016 to October 2021. Adult patients with sepsis at 10 acute-care hospitals in rural and urban areas across Missouri and Illinois were included. Inclusion criteria were blood cultures indicating sepsis, having received 4 days of antibiotic treatment, and having organ dysfunction (vasopressor use, mechanical ventilation, increased creatinine or bilirubin levels, and thrombocytopenia). Analyses were completed in April 2024. There are 11 data files: demographics, diagnoses, diagnoses_for_comorbidities, culture_w_sensitivities, labs, antibiotics, procedures, rooms_wards, vasopressors, vitals, and missing_labs. This study was approved by the Washington University in St. Louis Institutional Review Board (ID# 202109085).