Genome-wide analysis of alternative splicing evolution among Mus subspecies. Genome-wide analysis of alternative splicing evolution among Mus subspecies

We studied the evolution of alternative splicing in the early stages of species divergence in the house mouse. Overall design: We sequenced the testis transcriptomes of three Mus musculus subspecies and Mus spretus using Illumina technology. On the basis of a genome-wide analysis of read coverage differences among subspecies, we identified several hundred candidate alternatively spliced regions.