Renal and cardiac effects of the PDE9 inhibitor BAY 73-6691 in 5/6 nephrectomized rats.
收藏Figshare2023-10-16 更新2026-04-08 收录
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https://figshare.com/articles/dataset/Renal_and_cardiac_effects_of_the_PDE9_inhibitor_BAY_73-6691_in_5_6_nephrectomized_rats_/24305026
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资源简介：
We examined the effects of the PDE9 inhibitor BAY 73-6691 on the kidney and heart for the first time in a 5/6 nephrectomy animal model using BAY 73-6691 dosages known to be effective in other rat disease models. We did not observe any relevant effects of the PDE9 inhibitor BAY 73-6691 on renal function, renal histology, and renal disease-related pathways and gene expression in 5/6 nephrectomy rats. In addition, the effects of the PDE9 inhibitor BAY 73-6691 on the heart of 5/6 nephrectomy rats were mild. Except for cardiomyocyte size, BAY 73-6691 had no effect on other cardiac histological parameters, cardiac function, and disease-related genes and pathways.
提供机构：
Yin, Lianghong; Delić, Denis; Cao, Yaochen; Hocher, Berthold; CHEN, XIN; K· Krämer, Bernhard; Hasan, Ahmed A.; Gaballa, Mohamed M.S.; Wu, Hongwei; Zhang, Zeyu; Shen, Linghong; He, Ben; Klein, Thomas
创建时间：
2023-10-13
