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PATZ1 is a DNA damage responsive transcription factor that inhibits p53 function [with and without doxorubicin treatment]

NIAID Data Ecosystem2026-03-08 收录

DNA损伤应答

p53调控机制

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA291506 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2015-07-30

基因组稳定性

DNA损伤应答

Genomic stability is maintained by telomeres, the end terminal structures that protect chromosomes from fusion or degradation. Shortening or loss of telomeric repeats or altered telomere chromatin str

DataCite Commons2025-06-01 更新110

Phosphorylation of murine p53 at Ser-18 regulates the p53 responses to DNA damage

磷酸化调控

DNA损伤应答

Ser-15 of human p53 (corresponding to Ser-18 of mouse p53) is phosphorylated by ataxia-telangiectasia mutated (ATM) family kinases in response to ionizing radiation (IR) and UV light. To determine the

PubMed Central2000-10-17 更新50

Bleomycin exposed lymphoblastoid cells. Homo sapiens

癌症易感性

DNA损伤应答

The uncovering of genes involved in susceptibility to the sporadic cancer types is a great challenge. It is well established that the way in which an individual deals with DNA damage is related to the

NIAID Data Ecosystem40

Zalypsis: A novel marine-derived compound with potent antimyeloma activity

多发性骨髓瘤药物研发

DNA损伤应答

Multiple Myeloma (MM) remains incurable, and new drugs with novel mechanisms of action are still needed. In this report, we have analyzed the action of Zalypsis, an alkaloid analogous to certain natur

NIAID Data Ecosystem80

Roles of ATM and ATR-Mediated DNA Damage Responses during Lytic BK Polyomavirus Infection

病毒学

DNA损伤应答

BK polyomavirus (BKPyV) is an emerging pathogen whose reactivation causes severe disease in transplant patients. Unfortunately, there is no specific anti-BKPyV treatment available, and host cell compo

NIAID Data Ecosystem50

PATZ1 is a DNA damage responsive transcription factor that inhibits p53 function [with and without doxorubicin treatment]

资源简介：

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