Palladium-Catalyzed Intermolecular Dehydrogenative Aminohalogenation of Alkenes under Molecular Oxygen: An Approach to Brominated Enamines

A novel
and efficient palladium-catalyzed dehydrogenative aminohalogenation
of alkenes with molecular oxygen as the sole oxidant has been developed.
This protocol provides a valuable synthetic tool for the assembly
of a wide range of brominated enamines under mild conditions, with
unprecedented stereoselectivity and exceptional functional group tolerance.
This attractive route for the synthesis of brominated enamines is
of great significance due to the products’ versatile reactivity
for further transformations.