Melanoma is one of the most aggressive tumors with the remarkable characteristic of resistance to traditional chemotherapy and radiotherapy. Although targeted therapy and immunotherapy benefit advance

NIAID Data Ecosystem50

Debenzylative Cycloetherification as a Synthetic Tool in the Diastereoselective Synthesis of 3,6-Disubstituted Hexahydro‑2 H ‑furo[3,2‑ b ]pyrroles, PDE1 Enzyme Inhibitors with an Antiproliferative Effect on Melanoma Cells

黑色素瘤药物研发

磷酸二酯酶抑制剂

Two series of novel chiral hexahydro-2H-furo[3,2-b]pyrroles, 4-(7,8-dimethoxyquinazolin-4-yl) series A and 4-(6,7- dimethoxyquinazolin-4-yl) series B, were synthesized in enantiomerically pure form

NIAID Data Ecosystem40

The PPAR agonist Rosiglitazone induces paracrine signaling in melanoma cells that activate stromal cells and enhances tumor growth.. The PPAR agonist Rosiglitazone induces paracrine signaling in melanoma cells that activate stromal cells and enhances tumor growth.

黑色素瘤药物研发

肿瘤微环境

Besides improving insulin sensitivity in type 2 diabetes, the thiazolidinedione family of compounds and the pharmacologic activation of their best characterized target PPARg has been proposed as a the

NIAID Data Ecosystem70

Genome-wide expression profile of human melanoma cell line WM3248 treated with ARN22089 at 0, 4, 6 ÂµM dosing for 24 h

黑色素瘤药物研发

药物转录组学

To determine pathways engaged by ARN22089 in melanoma cells in-vitro; identify transcripts that are up- or down-regulated in the presence of ARN22089. Overall design: Human melanoma cell line (WM3248)

NIAID Data Ecosystem50

Supplemental Table 1 from Ceritinib Enhances the Efficacy of Trametinib in <i>BRAF/NRAS</i>-Wild-Type Melanoma Cell Lines

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