A Diastereodivergent Synthetic Strategy for the Syntheses of Communesin F and Perophoramidine

An efficient, unified,
and stereodivergent approach toward communesin
F and perophoramidine was examined. The C(3) all-carbon quaternary
center of an oxindole was smoothly constructed by base-promoted indolone-malonate
alkylation chemistry. The complementary relative stereochemistry of
the crucial vicinal quaternary centers found in communesin F and perophoramidine
was selectively installed by substrate-controlled decarboxylative
allylic alkylations.