Dataset phagocytic and oxidative activity after treatment by CC-195 and cefazolin

Supplementary data to the manuscript by Bukeyeva et al. "Dataset on the phagocytic and oxidative capacity of monocytes and granulocytes in the combined therapy of S.aureus infection in mice". Here we are the assessment of phagocytic and oxidative activity of mouse peripheral blood monocytes and granulocytes is presented in the complex therapy of cefazolin and coordination compound СC-195.
Bacterial pneumonia caused by the drug-resistant Staphylococcus aureus SCAID OTT1-2022 was treated for 5 days. The therapy was carried out both in a mono – a coordination compound CC-195 in a dosage of 10.0 mg/kg and a cefazolin antibiotic at a dosage of 25.0 mg/kg and also in combination CC-195 (10.0 mg/kg) + cefazolin (25.0 mg/kg). Blood samples were collected five days after treatment and five days after treatment was completed. This was done to evaluate how the immune system reacts to antibiotic discontinuation.

补充资料：Bukeyeva 等人撰写的关于小鼠金黄色葡萄球菌感染联合治疗中单核细胞和粒细胞吞噬及氧化能力的稿件。本研究展示了在头孢唑啉与配位化合物CC-195联合治疗过程中，对小鼠外周血单核细胞和粒细胞吞噬及氧化活性的评估。药物耐药性金黄色葡萄球菌SCAID OTT1-2022所致的细菌性肺炎经5天治疗后，在单用配位化合物CC-195（剂量为10.0 mg/kg）、头孢唑啉抗生素（剂量为25.0 mg/kg）以及CC-195（10.0 mg/kg）与头孢唑啉（25.0 mg/kg）联合治疗下进行。治疗结束后五天及治疗完成五天后收集血液样本，旨在评估免疫系统对抗生素停药的反应情况。