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Nickel-Catalyzed Oxidative Coupling of Unactivated C(sp3)–H Bonds in Aliphatic Amides with Terminal Alkynes

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Figshare2016-10-10 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Nickel-Catalyzed_Oxidative_Coupling_of_Unactivated_C_sp_sup_3_sup_H_Bonds_in_Aliphatic_Amides_with_Terminal_Alkynes/4004028
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In this work, we demonstrated Ni-catalyzed oxidative coupling of unactivated C­(sp3)–H bonds with terminal alkynes for construction of C­(sp3)–C­(sp) bonds to synthesize alkyl-substituted internal alkynes. Different amides exhibited good compatibility. Preliminary mechanistic studies were conducted to account for this alkynylation.
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2016-10-10
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