Regulation of genes expression in photoreceptor and other retinal cells by histone H3 tri-methylation at K27 during retinal development

To analyze roles of histone H3 tri-methylation for transcription in retina, global transcription patterns of retinal cells of Ezh2, H3K27 methylase, knockout mice and control were examined Examination of global mRNA expression patterns of mouse retinal cells fractioned into Cd73+ photoreceptors and Cd73- other retinal cells at postnatal 12 mouse为分析组蛋白H3三甲基化（histone H3 tri-methylation）在视网膜转录过程中的作用，本研究检测了组蛋白H3K27甲基转移酶（H3K27 methylase）Ezh2基因敲除小鼠及其对照小鼠的视网膜细胞全局转录模式；此外，还针对出生后12天小鼠的、经分选得到的Cd73阳性光感受器细胞（Cd73+ photoreceptors）与Cd73阴性其他视网膜细胞的全局mRNA表达模式展开了检测。