ClonalKinetic Data and Intermediate Results of SimiC

This dataset contains the ClonalKinetic dataset that was used in SimiC and its intermediate results for comparison. The Detail description can be found in the text file 'clonalKinetics_Example_data_description.txt' and 'ClonalKinetics_filtered.DF_data_description.txt'. The required input data for SimiC contains: 1. ClonalKinetics_filtered.clustAssign.txt => cluster assignment for each cell. 2. ClonalKinetics_filtered.DF.pickle => filtered scRNAseq matrix. 3. ClonalKinetics_filtered.TFs.pickle => list of driver genes. The results after running SimiC contains: 1. ClonalKinetics_filtered_L10.01_L20.01_Ws.pickle => inferred GRNs for each cluster 2. ClonalKinetics_filtered_L10.01_L20.01_AUCs.pickle => regulon activity scores for each cell and each driver gene. <b>NOTE:</b> “ClonalKinetics_filtered.rds” file which is mentioned in “ClonalKinetics_filtered.DF_data_description.txt” is an intermediate file and the authors have put all the processed in the pickle/txt file as described in the filtered data text.

本数据集包含用于SimiC的ClonalKinetic数据集及其用于比较的中间结果。详细的描述可查阅文本文件'clonalKinetics_Example_data_description.txt'及'ClonalKinetics_filtered.DF_data_description.txt'。SimiC所需输入数据包括：1. ClonalKinetics_filtered.clustAssign.txt => 每个细胞的聚类分配。2. ClonalKinetics_filtered.DF.pickle => 过滤后的单细胞RNA测序矩阵。3. ClonalKinetics_filtered.TFs.pickle => 驱动基因列表。运行SimiC后的结果包含：1. ClonalKinetics_filtered_L10.01_L20.01_Ws.pickle => 每个聚类的推断GRN。2. ClonalKinetics_filtered_L10.01_L20.01_AUCs.pickle => 每个细胞和每个驱动基因的调控子活性评分。<b>注意：</b>在'ClonalKinetics_filtered.DF_data_description.txt'中提到的'ClonalKinetics_filtered.rds'文件是一个中间文件，作者已将所有处理过程放入所述的pickle/txt文件中。