GR mutation in mice changes the genome-wide epigenome of frontal cortex in a highly sex-specific manner. GR mutation in mice changes the genome-wide epigenome of frontal cortex in a highly sex-specific manner

We found that the GR mutation leads to a changes of the DNA methylation landscape in frontal cortex of c57/bl6n male mice Overall design: Frontal cortex tissue of GR+/+ vs. glucocorticoid receptor-impaired (GR-i) mice was analyzed fro DNA methylation state on GR peaks genome-wide by GR-ChIP-bisulfite-sequencing