Chemical Elicitors for Activating Silent Biosynthetic Gene Clusters

Tables (Excel) Table S1.xlsx Dataset of chemical elicitors, activated biosynthetic gene clusters (BGCs), and induced products. Table S2.xlsx Potential elicitor analogs identified from DrugBank based on known chemical elicitors. Table S3.xlsx Potentially activatable homologous BGCs identified based on sequence similarity to known elicitor-activated BGCs. Table S4.xlsx Potentially activatable BGCs containing homologous regulatory genes responsive to known elicitors. Zipped datasets S1_knownBGC.zip Contains 32 known BGCs that can be activated by chemical elicitors. Detailed metadata and annotation for these BGCs are provided in Table S1. S3_homologousBGC.zip Contains 1,274 biosynthetic gene clusters that are highly homologous to the known elicitor-activated BGCs. Metadata for these homologous BGCs are provided in Table S3. S3_LCMS.zip Contains LC–MS/MS data for metabolites derived from Streptomyces albidoflavus sp. LHW61002 under elicitor-treated conditions. S4_RegulatoryGeneBGC.zip Contains 608 BGCs that include regulatory genes highly homologous to known elicitor-regulated genes. Metadata for these BGCs are provided in Table S4.