H4:IC31 and BCG induced immune responses in a prevention of M. tuberculosis infection efficacy trial

Immunogenicity responses from the C040-404 clinical trial were measured by whole blood intracellular cytokine staining at baseline and 70 days after vaccination with H4:IC31 (subunit vaccine containing Ag85B and TB10.4), Bacille Calmette-Guerin (BCG, a live attenuated vaccine) or placebo (n=~30 per group) using flow cytometry.

C040-404临床试验中，免疫原性反应通过全血细胞内细胞因子染色在疫苗接种前及疫苗接种后70天使用流式细胞术进行测量，疫苗包括H4:IC31（含Ag85B和TB10.4的亚单位疫苗）、卡介苗（BCG，一种减毒活疫苗）或安慰剂（每组约30人）。