Crystal structure of active Smoothened bound to SAG21k, cholesterol, and NbSmo8
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Crystal structure of active Smoothened bound to SAG21k, cholesterol, and NbSmo8 Descriptor: (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-chloro-4,7-difluoro-N-{[2-methoxy-5-(pyridin-4-yl)phenyl]methyl}-N-[trans-4-(methylamino)cyclohexyl]-1-benzothiophene-2-carboxamide, ... Authors: Deshpande, I.S, Liang, J, Hedeen, D, Roberts, K.J, Zhang, Y, Ha, B, Latorraca, N.R, Faust, B, Dror, R.O, Beachy, P.A, Myers, B.R, Manglik, A. Deposit date: 2019-02-26 Release date: 2019-07-03 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Smoothened stimulation by membrane sterols drives Hedgehog pathway activity. Nature, 571, 2019
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2019-02-26
