CNAs affecting transcription factor binding sites that may affect CRC related genes.

A: TFBS in regions where the copy number changes in excess of +/−35% are marked on chromosomes 7 (gain), 14 (loss), 20 (short arm gain (males), loss (females), long arm gain (both sexes)), 21 (loss) and X (somewhat similar to chromosome 20). The marking is by the gene names corresponding to these TFBS. B: Association of TFBS genes with significant functions and C: pathways. Cancer and TGF-β signaling were statistically the most significant associations for these affected genes.