Raw data - Ovariectomy induces regression of hyperplastic uterus in female dogs

This dataset contains raw and processed data from the original research study entitled “Ovariectomy induces regression of hyperplastic uterus in female dogs”, which evaluated the uterine involution in bitches diagnosed with cystic endometrial hyperplasia (CEH) after bilateral ovariectomy. The hypothesis tested was that the removal of steroidal hormonal influence through ovariectomy would induce regression of endometrial and glandular hyperplasia, observable macroscopically, histologically and immunohistochemically.
Data were collected over a 6-month period from 20 nulliparous bitches in diestrus or anestrus, selected and monitored by the Veterinary Hospital of the Federal University of Viçosa. The study included macroscopic analysis of the uterus, ultrasonographic measurements, histomorphometric evaluation, and immunohistochemistry for estrogen (ER) and progesterone receptors (PR), as well as the proliferation marker Ki-67. Each dog underwent an initial ovariectomy with right hysterectomy, and after six months, a left hysterectomy for comparative analysis. Uterine tissues were collected at both time points.
The dataset is composed of multiple files in .xlsx format, organized by subject ID and categorized according to: ultrasonographic uterine measurements before and after surgery, morphometric histological data (including uterine wall thickness, endometrial and myometrial measurements, glandular diameter and epithelial heights), immunohistochemistry scores (ER, PR, Ki-67), and CEH grading. Tables summarizing averages and standard deviations across subjects, as well as raw data tables, are included. Each variable is labeled, and a dictionary of terms is provided to ensure interpretability.
The findings derived from these data revealed that 88% of bitches showed at least a 50% reduction in total uterine wall thickness, with corresponding reductions in the endometrial and myometrial layers. Significant decreases in the expression of ER and PR receptors, as well as Ki-67, were observed in most subjects after six months. These findings support the conclusion that ovariectomy induces substantial uterine regression and can be considered an effective approach for CEH management in bitches.
This dataset may be valuable for researchers investigating uterine physiology, veterinary reproductive surgery, hormonal receptor dynamics, or canine endometrial pathology.