Table_1_v1_Effect of Body Mass Index on Outcomes of Percutaneous Nephrolithotomy: A Systematic Review and Meta-Analysis.docx

ObjectiveThe current study aimed to assess the efficacy and safety of percutaneous nephrolithotomy (PCNL) in obese and overweight individuals based on body mass index (BMI).MethodsWe electronically explored the databases of PubMed, CENTRAL, ScienceDirect, Embase, and Google Scholar databases for all types of comparative studies investigating the role of BMI on PCNL outcomes. Only studies defining obesity as >30 kg/m2 were included. Efficacy outcomes were stone-free rates and operating time while safety outcomes were complications and length of hospital stay (LOS).ResultsEighteen studies with 101,363 patients were included. We noted no difference in the stone-free rates after PCNL for morbid obese vs normal BMI patients (OR: 0.78 95% CI, 0.57, 1.08 I2 = 7% p = 0.13), overweight vs normal (OR: 1.01 95% CI, 0.89, 1.15 I2 = 1% p = 0.83) and obese vs normal patients (OR: 1.00 95% CI, 0.87, 1.16 I2 = 0% p = 0.95). PCNL operative time was significantly increased in morbid obese (MD: 9.36 95% CI, 2.85, 15.88 I2 = 76% p = 0.005) and obese patients as compared with normal patients (MD: 2.15 95% CI, 1.20, 3.10 I2 = 0% p

研究目的本项研究旨在基于体质量指数（BMI）评估肥胖及超重个体经皮肾镜取石术（PCNL）的疗效与安全性。研究方法我们通过PubMed、CENTRAL、ScienceDirect、Embase和Google Scholar数据库电子检索所有类型的研究，旨在探讨BMI对PCNL结果的影响。仅纳入将肥胖定义为>30 kg/m²的研究。疗效指标为无结石率与手术时间，安全性指标为并发症与住院时间。研究结果纳入了18项研究，涉及101,363名患者。我们发现，对于极度肥胖与正常BMI的患者，PCNL术后无结石率无显著差异（OR：0.78，95% CI：0.57，1.08，I² = 7%，p = 0.13），超重与正常BMI的患者（OR：1.01，95% CI：0.89，1.15，I² = 1%，p = 0.83）以及肥胖与正常BMI的患者（OR：1.00，95% CI：0.87，1.16，I² = 0%，p = 0.95）亦然。与正常患者相比，极度肥胖和肥胖患者的PCNL手术时间显著增加（MD：9.36，95% CI：2.85，15.88，I² = 76%，p = 0.005；MD：2.15，95% CI：1.20，3.10，I² = 0%，p = 0.005）。