Supplementary Material for: A MARKED EOSINOPHILIC INFILTRATION IN MUCOSA COULD BE A BETTER PREDICTIVE FACTOR FOR INTRACTABLE NON-ESOPHAGEAL EOSINOPHILIC GASTROINTESTINAL DISORDERS.

Introduction：Non-esophageal eosinophilic gastrointestinal disorders (non-EoE EGIDs) are rare, but their prevalence has recently increased. Although it has been reported that one-half of patients with non-EoE EGIDs have intractable clinical courses, their clinical features are not fully understood. Methods：This is a multicenter retrospective study in which 10 institutions in Japan participated. Clinical databases from January 1998 to December 2020 were reviewed to identify patients with non-EoE EGIDs. A total of 44 patients were identified; they were divided into two groups based on their clinical course: An intractable and a non-intractable group. The clinical features were compared between the two groups by a logistic regression analysis. Remarkable eosinophilic infiltration (REI) was defined histologically when the maximal counts of mucosal eosinophils reached a threshold level in the respective area of biopsy. Results：Prevalence of drug allergy, and eosinophil counts more than 500/μl (EOS), vomiting symptoms (Vomit), abnormalities of the stomach, duodenum and jejunum on computed tomography (UACT) and REI were significantly different between the two groups. Among the factors that were potentially associated with an intractable clinical course, logistic regression revealed that REI, EOS, and UACT were significant factors. Based on an analysis of the area under the ROC curve, a combination of REI and EOS had the lowest AIC, indicating the best model to predict an intractable clinical course. Conclusions：REI may predict an intractable course in patients with non-EoE EGIDs. In addition, the combination of REI and EOS was a better predictor than REI alone.