Fam60a defines a embryonic stem cell specific Sin3a/Hdac complex.
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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ChIP coupled with NGS identifies genome-wide binding sites of a ES cells specific Sin3a/Hdac complex.The aim of these experiments is to study the role of Fam60a in the Sin3a/Hdac complex. ChIP-Seq experiments reveal that Fam60a is required to maintain high levels of Sin3a binding on target genes in mESCs. Depletion of Fam60a causes a drop of Sin3a binding to target sites. Underlining the function of Fam60a in mES cells, ChIP-seq analysis of Sin3a and Fam60a in mouse fibroblasts reveal strikingly low global binding level of Sin3a to its target genes while Fam60a is absent at these sites.
提供机构：
Trinity College Dublin
创建时间：
2022-02-20
