Multi-omics analysis of dynamic dose-response in macrophages recapitulates multi-walled carbon nanotube -induced lung fibrosis [expression]. Multi-omics analysis of dynamic dose-response in macrophages recapitulates multi-walled carbon nanotube -induced lung fibrosis [expression]

Multi-omics approach to characterize the dynamic dose-dependent (DDD) molecular alterations in a model of human macrophages was used to highlight key-genes altered due to rCNT exposure. Results emphasize short and long term changes in gene regulation, that further suggest fibrotic responses, previously reported in in vivo animal model. Overall design: The gene expression profiles of THP-1 macrophages exposed to three concentrations (5, 10 or 20 µg/mL) of rigid multi-walled carbon and untreated controls were profiled at 24, 48 and 72 hours. Each group was performed as triplicates.