Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells

This dataset contains supplementary Excel tables related to the manuscript "Exosomal miR-302b Rejuvenates Aging Mice by Reversing the Proliferative Arrest of Senescent Cells." The data includes detailed quantitative analyses that support the findings of the study, covering aspects such as gene expression, cytokine levels, cell cycle phases, and the effects of miR-302b treatment on senescent cells and aging tissues.
The dataset comprises the following tables:

Table S1: Bulk RNA-seq data from PDL50 IMR-90 cells treated with hESC-Exos.
Table S2: Cell cycle phase proportions from single-cell RNA sequencing (scRNA-seq) of liver and skin tissues in aging mice.
Table S3: Pseudotemporal analysis of senescent cells transitioning to rejuvenated states.
Table S4: Cytokine profiling in serum samples of aging mice treated with or without hESC-Exos.
Table S5: Annotation of cell types in scRNA-seq data of liver and skin.
Table S6: Differentially expressed genes (DEGs) related to rejuvenation following hESC-Exos treatment.
Table S7: Composition of cell ratios in different experimental groups.
Table S8: Proportions of cells in various phases of the cell cycle.
Table S9: Rescue cell cycle-related genes (CCGs) shared between liver and skin tissues.
Table S10: Pseudotemporal analysis of mitotic cells in liver and skin tissues.
Table S11: Results from Ago2 CLIP-Seq analysis identifying miR-302b target genes.
Table S12: Absolute quantification of miR-302b abundance in different tissues.
Table S13: Bulk RNA-seq data from multiple tissues comparing young, aging, and miR-302b-treated mice.

本数据集收录了与论文《外泌体miR-302b通过逆转衰老细胞的增殖停滞来延缓衰老小鼠的衰老》相关的补充Excel表格。数据包含详尽的定量分析，旨在佐证研究结论，涵盖基因表达、细胞因子水平、细胞周期阶段以及miR-302b治疗对衰老细胞和衰老组织的影响等方面。

数据集包含以下表格：

Table S1：PDL50 IMR-90细胞接受人胚胎干细胞外泌体（hESC-Exos）处理后的大规模RNA测序数据。
Table S2：衰老小鼠肝脏和皮肤组织单细胞RNA测序（scRNA-seq）中细胞周期阶段的占比。
Table S3：衰老细胞向年轻状态过渡的拟时间序列分析。
Table S4：接受或未接受hESC-Exos治疗的老龄小鼠血清样本的细胞因子谱。
Table S5：肝脏和皮肤组织scRNA-seq数据中细胞类型的注释。
Table S6：hESC-Exos治疗后与年轻化相关的差异表达基因（DEGs）。
Table S7：不同实验组中细胞比例的组成。
Table S8：细胞周期不同阶段的细胞比例。
Table S9：肝脏和皮肤组织中共享的与细胞周期相关的基因（CCGs）。
Table S10：肝脏和皮肤组织中有丝分裂细胞的拟时间序列分析。
Table S11：Ago2 CLIP-Seq分析结果，识别miR-302b靶基因。
Table S12：miR-302b在不同组织中的绝对定量。
Table S13：比较年轻、衰老和miR-302b处理小鼠的多组织大规模RNA测序数据。