Structural determination of the A. niger RING finger domain
收藏ESRF Portal2028-01-01 更新2026-04-23 收录
下载链接：
https://doi.esrf.fr/10.15151/ESRF-ES-2308202822
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资源简介：
This project addresses the growing global cancer burden by focusing on targeted therapy approaches that disrupt cancer-specific pathways. It investigates the pro-cancer protein RBBP6, specifically the RING domain, which is key to ubiquitination. Unlike the canonical human C3HC4 RING motif, the Aspergillus niger RING domain contains an unusual cysteine-to-aspartic acid substitution, and the aim is to determine its structure to support anti-cancer drug discovery.
提供机构：
ESRF, 71 avenue des Martyrs CS 40220, 38043, Grenoble, FRANCE; ESRF, 71 avenue des Martyrs, CS 40220, 38043 Grenoble Cedex 9, France
创建时间：
2028-01-01
