Biphasic glucose-induced ΔψP depolarization is linked to stronger, but monophasic ΔψM hyperpolarization.

(A) ΔψP in glucose-stimulated rat β-cells. β-Cells were categorized into two groups based on ΔψP with monophasic (open symbols) or biphasic (closed symbols) response to 12–16 mM glucose. (B) ΔψM in β-cells categorized based on ΔψP in (A). Data are mean±SE of n = 4 experiments where individual categorized cells within each experiment were expressed as a single mean value. The p-value compares ΔψM (averaged in the interval of 30–60 min after glucose stimulation) between the two groups using paired t-test for experimental replicates.