Association of rs738409 with clinical traits.

Associations between distribution of rs738409 genotypes and clinical traits are calculated by multivariable regression. Statistical calculation1 is adjusted for age, sex and BMI, while the Matteoni types are additionally included as covariate in statistical calculation 2. Statistics are calculated by multivariable linear regression for biochemical traits and by multivariable ordinal logistic regression for immunological and histological traits.Coefficients and odds ratios are calculated for the increase of each trait per risk allele (G). The p-values showing significance after Bonferroni’s correction for multiple testing (p = 0.0021) was shown in bold.*Reciprocal numbers are used for normalization and a negative coefficient implicates an increase in value according to the increase of the risk allele.