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Tet2 negatively regulates memory fidelity

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NIAID Data Ecosystem2026-04-30 收录
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Tet2 functions in the CA1 as a negative regulator of long-term memory, and its haploinsufficiency in glutamatergic neurons or knockdown across the CA1 in mice is sufficient to enhance the fidelity of hippocampal-dependent spatial and associative memory. Overall design: Changes in DNA methylation was determined using whole genome bisulfite sequencing from glutamatergic Tet2 haploinsufficient CA1 tissue from mice.

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2022-11-16
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