DataSheet_1_Patterns and Trends of the Mortality From Bone Cancer in Pudong, Shanghai: A Population-Based Study.zip

IntroductionThe burden of cancer-related mortality of common malignancies has been reported worldwide. However, whether bone cancer (BC), as a highly aggressive and heterogeneous group of rare cancers, followed a similar or distinct epidemiological pattern during such process remains largely unknown. We aimed to analyze the mortality and the temporal trends of BC in relation to gender, age, and premature death in Shanghai, China.MethodsWe conducted a population-based analysis of the mortality data of BC in Shanghai Pudong New Area (PNA) from 2005 to 2020. The epidemiological characteristics and long-term trends in crude mortality rates (CMRs), age-standardized mortality rates worldwide (ASMRWs), and rate of years of life lost (YLL) was analyzed using the Joinpoint regression program. The demographic and non-demographic factors affecting the mortality rate were evaluated by the decomposition method.ResultsThere are 519 BC-specific deaths accounting for 0.15% of all 336,823 deaths and 0.49% of cancer-specific death in PNA. The CMR and ASMRW of BC were 1.15/105 person-year and 0.61/105 person-year, respectively. The YLL due to premature death from BC was 6,539.39 years, with the age group of 60–69 years having the highest YLL of 1,440.79 years. The long-term trend of CMR, ASMRW, and YLL rate significantly decreased by −5.14%, −7.64%, and −7.27%, respectively, per year (all p < 0.05) in the past 16 years. However, the proportion of BC-specific death within the total cancer-specific death dropped to a plateau without further improvement since 2016, and a remarkable gender and age disparity was noticed in the observed reduction in mortality. Specifically, the elderly benefited less but accounted for a larger percentage of BC population in the last decades. Although the overall mortality of BC decreased, there was still a significant upward trend toward an increased mortality rate caused by the aging of the BC patients.ConclusionOur study provides novel insights on the epidemiological characteristics and longitudinal dynamics of BC in a fast urbanization and transitioning city. As a rare disease affecting all ages, the burden of BC among the elderly emerged to form an understudied and unmet medical need in an aging society.

引言：癌症相关死亡率在全球范围内已有所报道。然而，作为一组高度侵袭性和异质性的罕见癌症，骨癌（BC）在上述过程中的流行病学模式是否与常见恶性肿瘤相似或迥异，至今仍鲜为人知。本研究旨在分析上海地区骨癌的死亡率和时间趋势，探讨其与性别、年龄以及早逝之间的关系。方法：本研究对上海浦东新区（PNA）2005年至2020年间骨癌的死亡率数据进行了基于人群的分析。利用Joinpoint回归程序，对骨癌的流行病学特征、粗死亡率（CMR）、全球标准化死亡率（ASMRW）以及预期寿命损失年（YLL）的长期趋势进行了分析。通过分解方法评估了影响死亡率的人口学和非人口学因素。结果：PNA地区共有519例骨癌特异性死亡，占所有死亡人数的0.15%，占癌症特异性死亡人数的0.49%。骨癌的CMR和ASMRW分别为1.15/105人年和0.61/105人年。因骨癌导致的早逝预期寿命损失年为6,539.39年，其中60-69岁年龄组损失寿命最高，达1,440.79年。在过去16年间，CMR、ASMRW和YLL率分别以每年−5.14%、−7.64%和−7.27%的幅度显著下降（所有p < 0.05）。然而，自2016年以来，骨癌特异性死亡在癌症特异性死亡中所占比例已趋于平稳，且未进一步改善，观察到死亡率的下降存在显著的性别和年龄差异。具体而言，老年人群受益较少，但在过去几十年中，骨癌患者中老年人群的比例却较大。尽管骨癌的整体死亡率有所下降，但由骨癌患者老龄化引起的死亡率上升趋势仍然显著。结论：本研究为快速城市化和转型中的城市骨癌的流行病学特征和长期动态提供了新的见解。作为一种影响所有年龄段的罕见疾病，老年人群中骨癌的负担凸显出来，成为老龄化社会中一个未被充分研究和满足的医疗需求。