The effects of ELF-1 on gene expression profiles of colonic tissue in DSS colitis at single cell level

The maintenance of intestinal homeostasis is closely related to the epithelial integrity and permeability.Elf-1 has been shown to play an important role in the development and maintenance of various hematopoietic lineages,as well as in the regulating the function of endothelial cells during tumor angiogenesis.Here, we characterized the intestinal cell landscape in DSS-induced model with Elf-1 deficiency at the single-cell level, and uncovered the disruption of intestinal immune homeostasis associated with Elf-1 deficiency. Colonic tissue were isolated from WT and Elf-1 knockout( Elf-1 KO) mice and analyzed with scRNA-seq