Additional file 1: of Transcriptional positive cofactor 4 promotes breast cancer proliferation and metastasis through c-Myc mediated Warburg effect

Table S1 QPCR Primer sequences used, Related to the Methods. Table S2. QPCR Primer sequences used either for PC4 chromatin immunoprecipitation, related to the Methods. Figure S1 Kaplan-Meier analysis for the association of PC4 expression (probe 212857_x_at and 214512_s_at) with overall survival time in breast cancer patients. Data was obtained using the Kaplan-Meier plotter. Figure S2. Silencing of PC4 have no significant impact on cell apoptosis in both MDA-MB-231 and MCF-7 cells. Figure S3 a MDA-MB-231 cells with stable PC4-knockdown were inoculated into female nude mice. The dissected xenografts were collected for immunohistochemical staining to detect the protein level of c-Myc, LDHA and Vimentin. b Statistical analysis of expression intensity derived from (a). Experiments were repeated three times independently. **p < 0.01, ***p < 0.001. (ZIP 17345 kb)