Crystal structure of pregnane X receptor ligand binding domain complexed with T0901317 analog SJPYT-318
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Crystal structure of pregnane X receptor ligand binding domain complexed with T0901317 analog SJPYT-318 Descriptor: N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-[(4-phenoxyphenyl)methyl]benzenesulfonamide, Nuclear receptor subfamily 1 group I member 2 Authors: Huber, A.D, Poudel, S, Miller, D.J, Li, Y, Chen, T. Deposit date: 2023-05-30 Release date: 2023-10-11 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand. Structure, 31, 2023
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2023-05-30
