Integrated Analysis of Environmental TDCPP Exposure, Hepatic Injury Biomarkers, and Transcriptomic Profiles in NHANES Participants with Liver Disease

This dataset contains curated research data investigating the association between urinary TDCPP metabolites and liver disease progression (hepatic steatosis [HS] and liver cirrhosis [LC]) using NHANES survey data (2017-2020 cycle). It includes:

Demographic/Clinical Variables: Age, sex, BMI, CAP (≥248 dB/m for HS), LSM (≥7.4 kPa for LC) from ARFI elastography (FibroScan®).

Exposure Data: Urinary TDCPP metabolite concentrations (values < LOD excluded).

Statistical Outputs:

RCS curves for dose-response relationships.

GVIF values for multicollinearity assessment.

IQR summaries of continuous variables.

Omics Data:

PPI network-identified hub genes (AKT1, STAT3, PPARG).

GO/KEGG enrichment results (PI3K-Akt, TGF-β pathways).

Immune infiltration scores (CIBERSORT algorithm).

Molecular docking binding energies for TDCPP-protein interactions.