Adipose Mesenchymal Cells-Derived Extracellular Vesicles Alleviate DOCA-salt-Induced Hypertension by Promoting Cardio-Renal Protection

By applying miRNA microarray profile of the kidney of DOCA-salt rats, we identified a selective miRNA signature associated with epithelial-mesenchymal transition (EMT) Renal cortex was isolated from DOCA-salt rats treated for 8-week with deoxycorticosterone acetate and high salt diet in the presence or not of EVs and compared with nephrectomized animals (UNX) and SHAM animals